Toluene-2,4-Diisocyanate. National Institute for Occupational Safety and Health (NIOSH). Molecular Weight 174.16 . Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. stream Hazard Summary . 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. In vitro cell transformation screening of 4 toluene diamine isomers. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). Flash point. (April 1996). Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). (February 1996). Relevant additional IBC req. (June 1998). Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . contact with product at elevated temperature s (>150c) can result in thermal burns. Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … 1.1. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Une revue de littérature réalisée par Bolognesi et al. 1989]. Baltimore, MD: The Williams and Wilkins Co., p. 141. 0000002356 00000 n trailer TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Beilstein/REAXYS Number 744602 . Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Gunter BJ [1975]. Viscosity @ 20°C Vapour pressure @ 20°C. https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. 0000000016 00000 n According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Risk of fire and explosion as a result of … 77, No. 100 mg. Price (USD) Price. 4th edition. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). 0000062501 00000 n %PDF-1.5 %���� Slightly hazardous in case of skin contact (corrosive). Methylene Bisphenyl Isocyanate. Potentially violent polymerization reaction with strong bases or acyl chlorides. Similarly, spray mists can impose a significant health hazard. 1989]. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Boiling points. 0000009752 00000 n CAS# 91-08-7. 0000006492 00000 n x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! 0000001869 00000 n MDL number MFCD00002011. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Email. Certificate of Analysis COA. : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . International Chemical Safety Cards (ICSC). 2. IBC carriage requirements. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … 17034 Classification. <>>> Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. Summary . 0000001270 00000 n Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. * Many scientists believe there is no safe level of exposure to a carcinogen. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. 0000008879 00000 n 1 15 U.S.C §2601 et seq. Main properties/hazards . Reaction with water to form Carbon Dioxide [Merck 11th ed. 0000001487 00000 n Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. View other preventive measures for 2,4-toluene diisocyanate in WISER. Methyl Isocyanate. 0000001407 00000 n <]>> [Handling Chemcials Safely 1980. p. 907]. Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. 1. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. 3 0 obj View other preventive measures for 2,4-toluene diisocyanate in WISER. Ambient (>5 °C) Safety Data Sheet SDS. Toluene Safety Data Sheet according to Federal Register / Vol. Toluene & Its Chemical Uses. 0000010616 00000 n This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). 0000066022 00000 n # D-5836-02N. Gosselin RE [1976]. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Main chemical and physical properties. Each notification may be associated with multiple companies. Each notification may be associated with multiple companies. 0000004304 00000 n 8. Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. (January 1986). %%EOF <> Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 90-117. ���Y? Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) 0000004561 00000 n 0 Melting point. 0000003775 00000 n The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. %���� Key health and ecological effects (hazard) Risk assessment outcomes. 0000052031 00000 n Reduction in diisocyanate-related occupational asthma is primarily … $25.00. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). For more detailed information, please visit ECHA C&L website … TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. [Handling Chemcials Safely 1980. p. 907]. Identification . Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. International Chemical Safety Cards (ICSC). - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. NZ Med J 63:642-647. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … 0000004899 00000 n Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. eye contact: may cause eye irritation. );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. 0000001666 00000 n 0000006881 00000 n When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Tank Type. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. startxref 0000005710 00000 n %PDF-1.5 Caution is advised. 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